Publications

Acute connexin43 temporal and spatial expression in response to ischemic stroke.
Moises Freitas-Andrade, Jennifer She, John Bechberger, Christian C Naus, Wun Chey Sin
J Cell Commun Signal 2018 Mar,12(1):193-204 Abstract

Matrix-assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in mice.
Jasmine S H Wang, Moises Freitas-Andrade, John F Bechberger, Christian C Naus, Ken K-C Yeung, Shawn N Whitehead
Rapid Commun. Mass Spectrom. 2018 Jun 30,32(12):951-958

Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture.
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
J Cell Commun Signal 2018 Jun 16 Abstract

Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics.
Christina L Grek, Zhi Sheng, Christian C Naus, Wun Chey Sin, Robert G Gourdie, Gautam G Ghatnekar
Curr Opin Pharmacol 2018 May 24,41:79-88 Abstract

Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.
Moises Freitas-Andrade, John F Bechberger, Brian A MacVicar, Victor Viau, Christian C Naus
Oncotarget 2017 Jun 06,8(23):36973-36983 Abstract

Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.
Andrei B Belousov, Joseph D Fontes, Moises Freitas-Andrade, Christian C Naus
BMC Cell Biol. 2017 Jan 17,18(Suppl 1):4 Abstract

Gap junctions and cancer: communicating for 50 years.
Trond Aasen, Marc Mesnil, Christian C Naus, Paul D Lampe, Dale W Laird
Nat. Rev. Cancer 2016 12,16(12):775-788 Abstract

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target.
Mathieu Charvériat, Christian C Naus, Luc Leybaert, Juan C Sáez, Christian Giaume
Front Cell Neurosci 2017,11:174 Abstract

Connexins and pannexins in Alzheimer’s disease.
Christian Giaume, Juan C Sáez, Weihong Song, Luc Leybaert, Christian C Naus
Neurosci. Lett. 2017 Sep 08 Abstract

Astrocytes promote glioma invasion via the gap junction protein connexin43.
W C Sin, Q Aftab, J F Bechberger, J H Leung, H Chen, C C Naus
Oncogene 2016 Mar 24,35(12):1504-16 Abstract

Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion.
Christian C Naus, Qurratulain Aftab, Wun Chey Sin
Semin. Cell Dev. Biol. 2016 Feb,50:59-66

Podoplanin: a marker for reactive gliosis in gliomas and brain injury.
Kushal Kolar, Moises Freitas-Andrade, John F Bechberger, Harini Krishnan, Gary S Goldberg, Christian C Naus, Wun Chey Sin
J. Neuropathol. Exp. Neurol. 2015 Jan,74(1):64-74

Gap junctions modulate glioma invasion by direct transfer of microRNA.
Xiaoting Hong, Wun Chey Sin, Andrew L Harris, Christian C Naus
Oncotarget 2015 Jun 20,6(17):15566-77  Abstract

Reduction in gap junction intercellular communication promotes glioma migration.
Qurratulain Aftab, Wun-Chey Sin, Christian C Naus
Oncotarget 2015 May 10,6(13):11447-64. Abstract

Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
M Freitas-Andrade, C C Naus
Neuroscience 2015 Apr 23. Abstract

Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress.
Hoa T Le, Wun Chey Sin, Shannon Lozinsky, John Bechberger, José Luis Vega, Xu Qiu Guo, Juan C Sáez, Christian C Naus
J. Biol. Chem. 2014 Jan 17,289(3):1345-54  Abstract

The pannexins: past and present.
Stephen R Bond, Christian C Naus
Front Physiol 2014,5:58 Abstract   

Pannexin 2 protein expression is not restricted to the CNS.
Maxence Le Vasseur, Jonathan Lelowski, John F Bechberger, Wun-Chey Sin, Christian C Naus
Front Cell Neurosci 2014,8:392 Abstract

Connexin multi-site phosphorylation: mass spectrometry-based proteomics fills the gap.
Vincent C Chen, Joost W Gouw, Christian C Naus, Leonard J Foster
Biochim. Biophys. Acta 2013 Jan,1828(1):23-34 Abstract

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.
Paul R Gielen, Qurratulain Aftab, Noreen Ma, Vincent C Chen, Xiaoting Hong, Shannon Lozinsky, Christian C Naus, Wun Chey Sin
Neuropharmacology 2013 Dec,75:539-48 [pmid:23688923] Abstract

Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
Michael G Kozoriz, Simon Lai, José L Vega, Juan C Sáez, Wun Chey Sin, John F Bechberger, Christian C Naus
Neuropharmacology 2013 Dec,75:549-56 [pmid:23727526] Abstract

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.
Christian Giaume, Luc Leybaert, Christian C Naus, Juan C Sáez
Front Pharmacol 2013,4:88 [pmid:23882216.  Abstract

RF-Cloning.org: an online tool for the design of restriction-free cloning projects.
Stephen R Bond, Christian C Naus
Nucleic Acids Res. 2012 Jul,40(Web Server issue):W209-13 [pmid:22570410] Abstract 

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control.
Vincent C Chen, Anders R Kristensen, Leonard J Foster, Christian C Naus
J. Proteome Res. 2012 Dec 7,11(12):6134-46

Role of gap junction protein connexin43 in astrogliosis induced by brain injury.
Nicolas Theodoric, John F Bechberger, Christian C Naus, Wun-Chey Sin
PLoS ONE 2012,7(10):e47311

Amyloid β-induced death in neurons involves glial and neuronal hemichannels.
Juan A Orellana, Kenji F Shoji, Verónica Abudara, Pascal Ezan, Edwige Amigou, Pablo J Sáez, Jean X Jiang, Christian C Naus, Juan C Sáez, Christian Giaume
J. Neurosci. 2011 Mar 30,31(13):4962-77

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes.
Stephen R Bond, Alice Lau, Silvia Penuela, Arthur V Sampaio, T Michael Underhill, Dale W Laird, Christian C Naus
J. Bone Miner. Res. 2011 Dec,26(12):2911-22

The connexin43 C-terminal region mediates neuroprotection during stroke.
Michael G Kozoriz, John F Bechberger, Geralyn R Bechberger, Michael W H Suen, Alonso P Moreno, Karen Maass, Klaus Willecke, Christian C Naus
J. Neuropathol. Exp. Neurol. 2010 Feb,69(2):196-206 Abstract

Implications and challenges of connexin connections to cancer.
Christian C Naus, Dale W Laird
Nat. Rev. Cancer 2010 Jun,10(6):435-41

The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells.
Sophie Crespin, John Bechberger, Marc Mesnil, Christian C Naus, Wun-Chey Sin
J. Cell. Biochem. 2010 Jun 1,110(3):589-97

Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.
Cima Cina, Karen Maass, Martin Theis, Klaus Willecke, John F Bechberger, Christian C Naus
J. Neurosci. 2009 Feb 18,29(7):2009-21 Abstract

Pannexin2 as a novel growth regulator in C6 glioma cells.
C P K Lai, J F Bechberger, C C Naus
Oncogene 2009 Dec 10,28(49):4402-8 Abstract    

Tumor-suppressive effects of pannexin 1 in C6 glioma cells.
Charles P K Lai, John F Bechberger, Roger J Thompson, Brian A MacVicar, Roberto Bruzzone, Christian C Naus
Cancer Res. 2007 Feb 15,67(4):1545-54  Abstract