Publications

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.
Freitas-Andrade, M., N. Wang, J. Bechberger, P. Lampe, L. Leybaert, and C.C. Naus.
J Exp Med. 2019. Apr 1;216(4):916-935. Abstract

Cx43-associated secretome and interactome reveal synergistic mechanisms for glioma migration and MMP3 activation.
Aftab Q., Mesnil M., E. Ojefua, A. Poole, J. Noordenbos, P-O. Strale, C. Sitko, C. Le, N. Stoynov, L.J. Foster, W.-C. Sin, C.C. Naus and V.C. Chen. 2019. Front. Neurosci. 13:143. Abstract

The gap junction protein pannexin 2 localizes at ER-mitochondria contact sites and sensitizes cells to apoptosis.
Le Vasseur, M., V.C. Chen, K. Huang, A.W. Vogl and C.C. Naus.
Cancers. 2019. Mar 11;11(3). Abstract

Connexins and pannexins in Alzheimer’s disease. In Special Issue of Neuroscience Letters on “Connexins and Pannexins in the Healthy and Diseased Nervous System”
Giaume, C., J. Saez, L. Leybaert, W. Song and C.C. Naus.
Neurosci. Lett. 2019. 695:100-105.

Functional validation of GJA1 as a master regulator of pathogenesis in Alzheimer’s disease. Kajiwara, E. Wang, M. Wang, W.C Sin, K. Brenand, E. Schadt, C.C. Naus, J. Buxbaum, B. Zhang. Acta Neuropathological Communications. 2018. 6(1):144.  Abstract

Acute connexin43 temporal and spatial expression in response to ischemic stroke.
Moises Freitas-Andrade, Jennifer She, John Bechberger, Christian C Naus, Wun Chey Sin
J Cell Commun Signal. 2018. Mar,12(1):193-204 Abstract

Matrix-assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in mice.
Jasmine S H Wang, Moises Freitas-Andrade, John F Bechberger, Christian C Naus, Ken K-C Yeung, Shawn N Whitehead
Rapid Commun. Mass Spectrom. 2018. Jun 30,32(12):951-958

Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture.
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
J Cell Commun Signal. 2018. Jun 16 Abstract

Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics.
Christina L Grek, Zhi Sheng, Christian C Naus, Wun Chey Sin, Robert G Gourdie, Gautam G Ghatnekar
Curr Opin Pharmacy. 2018. May 24,41:79-88 Abstract

Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.
Moises Freitas-Andrade, John F Bechberger, Brian A MacVicar, Victor Viau, Christian C Naus
Oncotarget. 2017. Jun 06,8(23):36973-36983 Abstract

Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.
Andrei B Belousov, Joseph D Fontes, Moises Freitas-Andrade, Christian C Naus
BMC Cell Biol. 2017. Jan 17,18(Suppl 1):4 Abstract

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target.
Mathieu Charvériat, Christian C Naus, Luc Leybaert, Juan C Sáez, Christian Giaume
Front Cell Neurosci. 2017.,11:174 Abstract

Gap junctions and cancer: communicating for 50 years.
Trond Aasen, Marc Mesnil, Christian C Naus, Paul D Lampe, Dale W Laird
Nat. Rev. Cancer. 2016. 12,16(12):775-788 Abstract

Connexins and pannexins in Alzheimer’s disease.
Christian Giaume, Juan C Sáez, Weihong Song, Luc Leybaert, Christian C Naus
Neurosci. Lett. 2017. Sep 08 Abstract

Astrocytes promote glioma invasion via the gap junction protein connexin43.
W C Sin, Q Aftab, J F Bechberger, J H Leung, H Chen, C C Naus
Oncogene. 2016. Mar 24,35(12):1504-16 Abstract

Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion.
Christian C Naus, Qurratulain Aftab, Wun Chey Sin
Semin. Cell Dev. Biol. 2016. Feb,50:59-66

Podoplanin: a marker for reactive gliosis in gliomas and brain injury.
Kushal Kolar, Moises Freitas-Andrade, John F Bechberger, Harini Krishnan, Gary S Goldberg, Christian C Naus, Wun Chey Sin
J. Neuropathol. Exp. Neurol. 2015. Jan,74(1):64-74

Gap junctions modulate glioma invasion by direct transfer of microRNA.
Xiaoting Hong, Wun Chey Sin, Andrew L Harris, Christian C Naus
Oncotarget. 2015. Jun 20,6(17):15566-77  Abstract

Reduction in gap junction intercellular communication promotes glioma migration.
Qurratulain Aftab, Wun-Chey Sin, Christian C Naus
Oncotarget. 2015. May 10,6(13):11447-64. Abstract

Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
M Freitas-Andrade, C C Naus
Neuroscience. 2015. Apr 23. Abstract

Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress.
Hoa T Le, Wun Chey Sin, Shannon Lozinsky, John Bechberger, José Luis Vega, Xu Qiu Guo, Juan C Sáez, Christian C Naus
J. Biol. Chem. 2014. Jan 17,289(3):1345-54  Abstract

The pannexins: past and present.
Stephen R Bond, Christian C Naus
Front Physiol. 2014. 5:58 Abstract   

Pannexin 2 protein expression is not restricted to the CNS.
Maxence Le Vasseur, Jonathan Lelowski, John F Bechberger, Wun-Chey Sin, Christian C Naus
Front Cell Neurosci .2014.8:392 Abstract

Connexin multi-site phosphorylation: mass spectrometry-based proteomics fills the gap.
Vincent C Chen, Joost W Gouw, Christian C Naus, Leonard J Foster
Biochim. Biophys. Acta. 2013. Jan,1828(1):23-34 Abstract

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.
Paul R Gielen, Qurratulain Aftab, Noreen Ma, Vincent C Chen, Xiaoting Hong, Shannon Lozinsky, Christian C Naus, Wun Chey Sin
Neuropharmacology 2013 Dec,75:539-48 Abstract

Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
Michael G Kozoriz, Simon Lai, José L Vega, Juan C Sáez, Wun Chey Sin, John F Bechberger, Christian C Naus
Neuropharmacology. 2013. 75:549-56 Abstract

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.
Christian Giaume, Luc Leybaert, Christian C Naus, Juan C Sáez
Front Pharmacie. 2013. 4:88 Abstract

RF-Cloning.org: an online tool for the design of restriction-free cloning projects.
Stephen R Bond, Christian C Naus
Nucleic Acids Res. 2012. Jul,40(Web Server issue):W209-13  Abstract 

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control.
Vincent C Chen, Anders R Kristensen, Leonard J Foster, Christian C Naus
J. Proteome Res. 2012. Dec 7,11(12):6134-46

Role of gap junction protein connexin43 in astrogliosis induced by brain injury.
Nicolas Theodoric, John F Bechberger, Christian C Naus, Wun-Chey Sin
PLoS ONE 2012,7(10):e47311

Amyloid β-induced death in neurons involves glial and neuronal hemichannels.
Juan A Orellana, Kenji F Shoji, Verónica Abudara, Pascal Ezan, Edwige Amigou, Pablo J Sáez, Jean X Jiang, Christian C Naus, Juan C Sáez, Christian Giaume
J. Neurosci. 2011. Mar 30,31(13):4962-77

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes.
Stephen R Bond, Alice Lau, Silvia Penuela, Arthur V Sampaio, T Michael Underhill, Dale W Laird, Christian C Naus
J. Bone Miner. Res. 2011. Dec,26(12):2911-22

The connexin43 C-terminal region mediates neuroprotection during stroke.
Michael G Kozoriz, John F Bechberger, Geralyn R Bechberger, Michael W H Suen, Alonso P Moreno, Karen Maass, Klaus Willecke, Christian C Naus
J. Neuropathol. Exp. Neurol. 2010. Feb,69(2):196-206 Abstract

Implications and challenges of connexin connections to cancer.
Christian C Naus, Dale W Laird
Nat. Rev. Cancer. 2010. Jun,10(6):435-41

The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells.
Sophie Crespin, John Bechberger, Marc Mesnil, Christian C Naus, Wun-Chey Sin
J. Cell. Biochem. 2010. Jun 1,110(3):589-97

Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.
Cima Cina, Karen Maass, Martin Theis, Klaus Willecke, John F Bechberger, Christian C Naus
J. Neurosci. 2009. Feb 18,29(7):2009-21 Abstract

Pannexin2 as a novel growth regulator in C6 glioma cells.
C P K Lai, J F Bechberger, C C Naus
Oncogene. 2009. Dec 10,28(49):4402-8 Abstract    

Tumor-suppressive effects of pannexin 1 in C6 glioma cells.
Charles P K Lai, John F Bechberger, Roger J Thompson, Brian A MacVicar, Roberto Bruzzone, Christian C Naus
Cancer Res. 2007. Feb 15,67(4):1545-54  Abstract